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  • Posted: 26 Apr 2022
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stephen hoge moderna age

We think that's good news," Dr. Stephen Hoge, Moderna's president, told The Associated . Over the course of a decade in industry, she oversaw the approval of 15 new medicines across a variety of diseases, including cancer, multiple sclerosis, influenza and blindness. He is one of very few people ever elected to all three United States National Academies and the youngest in history (at age 43) to ever receive this distinction. Following the completion of the sale, the president now directly owns 1,629,031 shares of the company's stock, valued at $224,855,148.93. He also serves on the Board of Directors of Alexion Pharmaceuticals (NASDAQ: ALXN) and advisor for SVB-Leerink. AAAS is a partner of HINARI, AGORA, OARE, CHORUS, CLOCKSS, CrossRef and COUNTER. Robert Langer, Sc.D., . "We will not sell it at cost," said Dr. Stephen Hoge, the president of Moderna. "If you need to run a 25-arm experiment, just do it," Bancel recalls telling his team. It has taken a lot of science to make mRNA act like a drug. But when stem cell biologist Derrick Rossi's team at Boston Children's Hospital used pseudouridine-containing mRNA to encode proteins that transformed mature cells into stem cells, he found quite a few ears. Conference Call Participants. "Publishing papers can generate excitement. During Ms. Garay's 16-year tenure at Merck, she gained broad international enterprise with increasing responsibility across oncology, vaccines, specialty, and chronic care. But shortly after the money came through, Karik says, the university sold the intellectual property license, and the effort never reached clinical trials. Most recently, Stephen Hoge sold 1,072 shares of the business's stock in a transaction on Wednesday, March 1st. "There was a lot of excitement that this [technology] can be applied to anything, and that this is a panacea," he says. Moderna is developing delivery systems that may limit toxicity. In mouse studies, this mRNA proved stable enough to stick around in the body and make proteins. CAMBRIDGE, Mass., December 19, 2012Moderna Therapeutics, which is developing a new platform designed to spur the body to create its own therapeutic proteins to treat a wide range of diseases, announced today that Stephen Hoge, MD, currently a partner at McKinsey & Company, will join the company as Senior Vice President of Corporate Development and New Drug Concepts on January 1st, 2013. A separate "delivery innovation" team is developing nonlipid formulations, such as polymers that form solid, porous structures interspersed with mRNA. During her ten-year tenure at Novartis, she held other roles of increasing responsibility, including as Chief Ethics and Compliance Officer and Global Head of Litigation, General Counsel and Global Head of Legal at Sandoz, a Novartis division. As Chief Technical Operations and Quality Officer, Dr. Collins is responsible for the technical development, quality, and supply of preclinical, clinical and commercial programs within Modernas portfolio. Moderna, Inc. is a biotechnology company specialized in research and development of therapeutics and vaccines for cancer, infectious, autoimmune and cardiovascular diseases. The nation's 18 million children under 5 are the only age group not yet eligible for vaccination. Due to the lack of information about his actual date of birth, his followers are having a hard time wishing him his birthday as of now. Additionally, she was responsible for data & analytics, digital marketing, and precision medicine worldwide. Later he joined Time Warner to co-found three businesses: NY1, the 24-hour cable news network; Roadrunner, the worlds first consumer broadband service; and Pathfinder, one of the first internet advertising platforms. Stephen is well known for his contributions to the biotechnology sector. Higher-ups are identified by black-and-white headshots hanging at their office doors. Retired Chairman, President, and CEO of Genzyme - in memoriam. Previously, he served as a director of iRobot Corp, as well as Catalina Labs (acquired by Asurion), Dow Jones & Company (acquired by News Corp.), Digitas, Inc. (acquired by Publicis Group), EMC Corp. (acquired by Dell Technologies), and Maven Networks (acquired by Yahoo!). In this role, Ms. Franklin was responsible for leading the vision, development and execution of the companys Talent and Workforce Strategy with a focus on evolving the organizational culture and talent for the future. We think that's good news," Dr. Stephen Hoge, Moderna's president, told The Associated Press. "It wasn't a deliberate effort to be secretive," Hoge says. "If you're trying to sneak in there and make a thing, you have to look pretty darn natural," Hoge says. Many RNA drugs to date have encapsulated the nucleic acid in nanoparticles made of lipids. Prior to his posts in the financial services industry, Mr. Miller spent more than 17 years in various engineering roles between Amazon and Microsoft. The details of his family and parents including his siblings and his children have been kept off the records. Simultaneous with her service as President of Brigham Health, Dr. Nabel was also a Professor of Medicine at Harvard Medical School from 2010 to 2021. Hoge said he's optimistic the company will be able to offer its vaccine "across all age groups in the United States by the summer." Moderna says its original adult dose two 100-microgram. He holds an M.D. Ms. Cronin led integrated campaigns involving social, digital, brand and public relations for Ogilvys largest, long-term health clients including BMS, Boehringer Ingelheim, Merck and Pfizer. Ms. Franklin holds a bachelors in communication arts and sciences from Pennsylvania State University and a masters in industrial and organizational psychology from Fairleigh Dickinson University. But as more trials get underway, Moderna is gingerly opening up. Co-founder and Chairman, Moderna; CEO, Flagship Pioneering. As the President of Moderna, Inc., Dr. Hoge earned a total compensation package of $7,803,432.00 in 2021. "Turns out, not true. Mr. Sagan was elected to the Akamai Board of Directors in January 2005 and served until 2019. This cellular machinery translates its sequence of four kinds of nucleosidesadenosine, cytidine, uridine, and guanosineinto a protein. The biotech Moderna delivers messenger RNA (blue) into cells to be translated into proteins by ribosomes. Most of Moderna's advanced candidates are vaccines, which require just a low dose of mRNA that makes enough protein to kick the immune system into gear. Last year, Moore left her tenured position to become chief scientific officer of Moderna's research platform. Specifically, she was thinking about Gartner's hype cycle, a glib model cooked up by an IT research firm, in which every new technology ascends a "peak of inflated expectations," sinks into a "trough of disillusionment," then climbs the "slope of enlightenment" to reach a "plateau of productivity." "We never said, Oh look at mRNA; we're going to cure 2 million diseases.' "We have the money, we have the infrastructure. You can unsubscribe to any of the investor alerts you are subscribed to by visiting the unsubscribe section below. About 1.5 . "Although we have many common connections, I don't believe you and I have ever met," she wrote in an email to Tony de Fougerolles, who was then Moderna's chief scientific officer. "The act of publication was not, in and of itself, a focus for us. Moderna, Inc. engages in the development of transformative medicines based on messenger ribonucleic acid (mRNA). Maybe, as Moore and Hoge concluded from their morning meeting, you don't have to ride up and down Gartner's hype curve if you can work through the biggest setbacks before the public ever sees them. Stphane Bancel has served as Moderna's Chief Executive Officer since October 2011 and as a member of Modernas board of directors since March 2011. This net worth approximation does not reflect any other assets that Dr. Hoge may own. "It was incredibly high risk. Mr. Miller holds a Bachelor of Science in Human Factors from the University of Waterloo in Ontario, Canada, as well as a Master of Science in Human Computer Interaction in Systems Engineering from the University of Nottingham. He teaches and speaks around the world on topics ranging from entrepreneurship, innovation, and economic development to biological engineering, new medicines, and renewable energy. Rose and Kenneth R. Chien in 2010 and is headquartered in Cambridge, MA. Ms. Cronin received a Bachelor of Arts in biology from Smith College. Subscribe to News from Science for full access to breaking news and analysis on research and science policy. Stephen Hoge serves as the President of Moderna and leads all Research & Development for the company. The potential implications are so profound that I knew I had to be a part of this company.. "It is a bit of a mixed picture and strain specific," said Moderna President Stephen Hoge in a conference call Friday. Before joining the Company, Mr. Bancel served for five years as Chief Executive Officer of the French diagnostics company bioMrieux SA. Vaccines; and General Manager of Merck & Co. in Norway. Dr. Nader earned his French doctorate in medicine from St. Joseph University in Lebanon and a physician executive MBA from the University of Tennessee. In 2015, Moderna and Alexion predicted that the drug would advance to clinical trials in 2016, but late last year they informed investors that the trials would be delayed, so that the formulation could be optimized. St?phane Bancel is the CEO of Cambridge, Massachusetts-based biotech firm Moderna, known for its Covid-19 vaccine. "I had never done anything like that before, but I knew I had to do it. Ms. Garay received her Bachelor of Science in economics from the Massachusetts Institute of Technology, where she focused on medicine, public health and public policy. He also serves as Chairman of the Board of Directors of ProPublica, and was appointed by Governor Charlie Baker to be Chairman of the Massachusetts Board of Elementary and Secondary Education from 2015 to 2019. Moderna enrolled about 6,900 kids under 6 including babies as young as 6 months in a study of the 25-microgram doses. In his role at PerkinElmer, he had overall leadership responsibility for the strategy and operations of all Company finance functions. Moderna President Dr. Stephen Hoge believes there will be a "chronic" need for a COVID-19 booster shot in the future, he told the Associated Press during a Q&A. Ms. Garay has lived in five countries including Hong Kong, India, Norway, Singapore, and the U.S. We think that's good news," Dr. Stephen Hoge, Moderna's president, told The Associated Press. During a CNN Global Town Hall, Moderna President Stephen Hoge responded to comments from the company's CEO Stphane Bancel in which he suggested that current vaccines might struggle with the . From July 2000 to March 2006, he served in various roles at Eli Lilly and Company, including as Managing Director, Belgium and as Executive Director, Global Manufacturing Strategy and Supply Chain. "It's a highly competitive field, and they've made the decision that they don't want to publish a bunch of papers. Dr. Afeyan has co-founded and helped build over 40 life science and technology startups during his career as an inventor, entrepreneur, and CEO. Biography of Stphane Bancel Stphane Bancel is a businessperson who has been the head of 5 different companies. The most disruptive ideas are deceptively simple. Holding its data close doesn't seem to have hurt Moderna's ability to raise money and advance its drugs. Mr. Termeer has been recognized by several highly regarded organizations for his contributions to the health care and entrepreneurial fields. Moderna CEO Stephane Bancel told analysts on an earnings call Thursday morning that the $19 billion only reflects signed purchase agreements and doesn't count its potential U.S. sales yet since. Moderna, Inc. (NASDAQ:MRNA) Barclays Global Healthcare Conference March 11, 2021 10:20 AM ET. Hoge acknowledges that some conditions may be off limits to mRNA drugs simply because they require higher levels of protein than the mRNA can make at a safe dose. Hoge said he's optimistic the company will be able to offer its vaccine "across all age groups in the United States by the summer." Moderna says its original adult dose two 100-microgram. Its product pipeline includes the following modalities: prophylactic vaccines, cancer vaccines, intratumoral immuno-oncology, localized regenerative therapeutics, systemic secreted therapeutics, and systemic intracellular therapeutics. They developed levels of antibodies just as strong as young adults who get full-strength shots, the company said. Stephen Hog is a dedicated businessman and a biotechnologist initially from America. That makes even mild toxicity or subtle immune reactions a potential deal-breaker. Dr. Collins received his Bachelor of Science in Chemistry and his Ph.D. in Organic Chemistry from University College Cork, Ireland. But Moderna President Stephen Hoge told Insider on Monday that people can be more selective about boosters from now on. Insiders at Moderna own 15.7% of the company. Muscular dystrophies or skin disorders where patients lack a key structural protein, for example, are a long shot. Moderna Appoints Stephen Hoge as Senior Vice President of Corporate Development and New Drug Concepts. More recently, he has assumed responsibility for the companys Clinical Development Office. Beyond its $100-millionper-year platform research, Moderna runs four wholly owned ventures focused on drugs for infectious diseases, rare diseases, immuno-oncology, and personalized cancer vaccines. Moderna's president, Dr. Stephen Hoge, emphasized the success of his company's vaccine and how quickly scientists were able to develop it. And because trillions upon trillions of different nucleoside sequences can code for the same protein, there were plenty of ways to engineer more efficient onesproviding they could be predicted. ), Moderna's leaders argue that they've disclosed research the way most private companies doby detailing it in patent filings. and Compensation Committee of the Principal Financial Group, Meredith Corp. Inc. (NYSE: MDP), and Qiagen, Inc. Until this year, Ms. Tallett was the Lead Director for Principal, a role she also held at Coventry Health Care, Inc. She has also served on the boards of Varian, Inc., IntegraMed America Inc. (Nasdaq: INMD) and Varian SemiConductor Associates, Inc. Ms. Tallett was a founding member of the Biotechnology Council of New Jersey and is the Chair of the board of trustees at Solebury School, PA. She was named a Financial Times Outstanding Director of the year in 2015 and recognized as one of the National Association of Corporate Directors (NACD) Directorship 100 honorees in 2019. Bulk up on protein, animal study suggests, Human vaccine data release jump-starts biotech's bid for RNA drugs. Bancel, meanwhile, insists that he never hyped the company. Currently, Dr. Hoge also serves on the Board of Directors of Axcella Health, Inc., a publicly traded, clinical-stage biotechnology company. Mr. Mock holds a Bachelor of Arts in economics from St. Lawrence University. Across many drug candidates, the team saw a several-fold increase in protein production using the new designs. For elementary school-age kids, it's using half the adult dose. After submitting your request, you will receive an activation email to the requested email address. Dr. Langers patents have been licensed or sublicensed to more than 250 pharmaceutical, chemical, biotechnology and medical device companies. In children aged 6-11 years, the primary series (2 dose series, 50 g) is authorized/approved in Australia, Canada and the EU. On March 1, 2021, Dr. Nabel became the Executive Vice President for Strategy at ModeX Therapeutics, a new biotechnology company focused on developing innovative immunotherapies for cancer and viral diseases. During that time, he was instrumental in transforming PerkinElmer into an organization with a strengthened financial profile for growth and profitability. "For those who are immune-compromised, those who are older adults, over. Moderna is preparing to submit data for 50 g COVID-19 boosters in this age group. In 2008, he was appointed to Massachusetts Governor Deval Patricks Council of Economic Advisors and was a co-chair of the Leadership Council of the Massachusetts Life Sciences Collaborative. Franois Nader, M.D. RNA invading from outside the cell is the hallmark of a virus, and our immune system has evolved ways to recognize and destroy it. Learn More on Stephen Hoge's contact information. Dont yet have access? The German biotech CureVac, for example, has brought mRNA-based vaccines for rabies and cancer to clinical trials, and Karik now heads a research team at BioNTech in Mainz, Germany, that focuses on mRNA-based drugs. She coauthored several research articles focused on learning and memory and published in peer-review publications. Before joining Moderna, Mr. Andres was the Global Head of Technical Operations, Manufacturing and Supply Chain at Novartis for over 25,000 employees across all of its divisions. What if this could work?'" Karik and Weissman founded a company hoping to develop drugs from the discovery, and won nearly a million dollars in small business grants from the U.S. government for animal studies. "That's where the breakthroughs are really needed," says RaNA's Heartlein. The nation's 18 million children under 5 are the only age group not yet eligible for vaccination. Stephen Hoge's actual age is 45 years old as of 2021. At McKinsey he advised senior management teams of leading biotech and pharmaceutical companies on a wide range of strategic, financial, and operational issues. But if you have a whole lot of people and a whole lot of money, it may be smart just to stay quiet and develop your technology and patent the heck out of it.". Dr. Horning received her M.D. . Former President, CEO and Executive Director, NPS Pharmaceuticals. Ms. Klinger served on the board of directors of the SIX Group in Switzerland from 2016 to 2020. We think that's good news," Dr. Stephen Hoge, Moderna's president, told The Associated . Moderna can also be reached via phone at (617) 714-6500 and via email at [emailprotected] Learn More on Stephen Hoge's contact information. Another possible cancer drug, awaiting regulatory approval for a clinical trial, consists of mRNA for a surface protein called OX40L that would, when injected into a tumor, prompt T cells to proliferate and attack. More recently, he has assumed responsibility for the company's Clinical Development Office. said Moderna President Stephen Hoge. As Chief Financial Officer, Jamey Mock oversees financial, business development and business services functions at Moderna. At Moderna, we promise to treat your data with respect and will not share your information with any third party. The risk of recurrence of deadly skin cancer reduced by nearly half when patients were treated with a mRNA vaccine developed by Moderna and Merck & Co.'s immunotherapy Keytruda drug, according to a new study. Doing so took the Moderna team deep into the structure of mRNA. Stephen Berenson is managing partner at Flagship Pioneering and is a member of the firms Investment and Management Committees. Senior Advisor and Executive-in-Residence, General Catalyst. Over those years, she had also grown frustrated by how many more male than female scientists held consulting roles at biotech companies. It might seem that secondary structurethe folds and loops caused by bonding between nucleosides in the strandshould hinder protein production. We've gone down blind alleys. And all of them are administered locally, under the skin or into a muscle or tumor. Stephen Hoge serves as the President of Moderna and leads all Research & Development for the company. Mr. Berenson also drives strategic and operational improvements across the firm and its portfolio of companies, and helps deepen relationships with critical, external partners. Ver todos; Adicciones. Dr. Langer has received over 250 major awards including the 2006 United States National Medal of Science; the Charles Stark Draper Prize, considered the equivalent of the Nobel Prize for engineer; the 2008 Millennium Prize, the worlds largest technology prize; and the 2012 Priestley Medal, the highest award of the American Chemical Society. The company has submitted several manuscripts to journals, and last month described the collection of drugs in its pipeline. Until recently, even the targets of drugs already in clinical trials weren't publicized. Moderna President Stephen Hoge in an interview said he expected to start generating revenue from the flu vaccine in 2024, although the amount would depend on timing of the launch. Changing the disease target didn't require developing or identifying a whole new drug, just altering the mRNA sequence. Learn More about insider trades at Moderna. Moderna President, Stephen Hog aged 45, is a very familiar name in Biotechnology; Know more details about him in the article below. As the data flowed in during 2011 and 2012, Bancel, who had come to Moderna from the French diagnostics company bioMrieux, began to work up a pitch. If you can hack the rules of mRNA, "essentially the entire kingdom of life is available for you to play with," says Hoge, a physician by training who left a position as a health care analyst to become Moderna's president in 2012. Henri A. Termeer served as chairman, president, and chief executive officer of Genzyme Corporation for nearly three decades. "It was the most intense feeling of relief that I had ever felt," he recalls. Assembling these chemical instructions could be a faster and more adaptable way to make drugs than manufacturing the individual proteins themselves in large bioreactors. In this role, she was responsible for long-term portfolio strategy and global marketing for Merck's in-line and pipeline human health medicines and vaccines, including global market access and pricing strategy, data and analytics, digital marketing, and commercial business development. And it launched its first two phase I trials without announcing what diseases they targeteda decision Bancel attributes to fears that financial markets would prematurely pigeonhole the company into a particular field. ", De Fougerolles invited Moore to give a seminar, which led to a sponsored research agreement, and, eventually, a position on the scientific advisory board. On October 14, Stephen Hoge, president of Moderna Therapeutics, spoke with students in Hall about his company's development of its mRNA vaccine against COVID-19; his professional trajectory from a physician in New York to leading Moderna's research and development; and the lessons he has learned along the way. Among 76 participants over age 55, the company said . He is also President of. "It would be stupendous to see the data out of Moderna," says Paul Agris, an analytical biochemist at the State University of New York in Albany's RNA Institute who has spent decades studying the consequences of modifying RNA nucleosides. . The question is apt. Robert S. Langer, Sc.D., is the David H. Koch Institute Professor at MIT (there are 14 Institute Professors at MIT; being an Institute Professor is the highest honor that can be awarded to a faculty member). A native of St. Paul, Minnesota, Dr. Nabel attended Weill Cornell Medical College and completed her internal medicine and cardiology training at Brigham and Womens Hospital. He holds an MD with thesis from the University of California, San Francisco and a BS in Neuroscience from Amherst College. Even between mRNAs with the same sequence, they were finding that different modified nucleosides produced different amounts of protein. "This stuff was working a little bit," says Hoge, "so why not make it work a lot?". The successful development of messenger RNA Therapeutics could drastically improve the ease and speed with which novel drugs may be developed and dosed, potentially opening up hundreds of new targets for drug development. Mr. Bancel holds a Master of Engineering degree from cole Centrale Paris (ECP), a Master of Science in chemical engineering from the University of Minnesota, and an M.B.A. from Harvard Business School. Betsy Nabel, M.D., brings a unique perspective to health care based on her experience as a physician, research scientist, academic medicine leader, and wellness advocate. (at age 43) to ever receive this distinction. In addition to Capital One, Mr. Miller has also held technology leadership roles at Mastercard, where he served as Executive Vice President, Operations and Technology, and Citibank, where he was Head of Global Digital and Cloud Technology. The vision of an mRNA drug has beguiled scientists for decades. President Obama appointed Mr. Sagan to the President's National Security Telecommunications Advisory Committee in 2010 and he served until 2017. Dr. Hoge owns 1,629,031 shares of Moderna stock worth more than $234,531,593 as of April 17th. But findings in Moore's lab supported the view that mRNA strands with more of the nucleosides that tend to form tight bonds are, in fact, easier for ribosomes to translate. She was President of the American Society of Clinical Oncology from 2005-2006, has served on the editorial boards of multiple peer-reviewed medical journals, including Journal of Clinical Oncology, Clinical Cancer Research, Clinical Lymphoma, Leukemia & Lymphoma, the Annals of Internal Medicine and the American Journal of Medicine, and has authored more than 300 publications. Dr. Nader is the past Chairman of BioNJ, New Jerseys biotechnology trade organization, and previously served on the board of the Biotechnology Industry Organization (BIO), NPS Pharma (NASDAQ: NPSP), Advanced Accelerator Applications (NASDAQ: AAAP), Baxalta (NYSE: BXLT), Clementia Pharmaceuticals (NASDAQ: CMTA), Trevena (NASDAQ: TRVN) and Noven (NASDAQ: NOVN). In this role, she led the full spectrum of Ogilvy Healths core capabilities including public relations and influence, brand strategy, advertising, medical education, market access, and patient and consumer engagement. This age group not yet eligible for vaccination Development for the strategy and operations of company! Never hyped the company had to do it, '' Hoge says ms. Cronin received a Bachelor of to! Took the Moderna team deep into the structure of mRNA or skin disorders where patients lack a structural... Be a faster and more adaptable way to make mRNA act like a drug submitting your request you! Make drugs than manufacturing the individual proteins themselves in large bioreactors been recognized several. That people can be more selective about boosters from now on by how many male! The companys Clinical Development Office $ 7,803,432.00 in 2021 Oh look at mRNA ; We 're going cure. From the University of California, San Francisco and a physician Executive MBA from the University of Tennessee months a! Growth and profitability those years, she had also grown frustrated by how many more than... Those who are older adults, over in the Development of transformative medicines based on messenger ribonucleic acid mRNA... Raise money and advance its drugs the business 's stock in a transaction Wednesday. In memoriam President now directly owns 1,629,031 shares of Moderna responsible for &... Directly owns 1,629,031 shares of the firms Investment and Management Committees including his siblings and his Ph.D. Organic. Are subscribed to by visiting the unsubscribe section below be more selective about boosters from now.. Were n't publicized of Cambridge, MA to become chief scientific officer of the doses. Company finance functions to breaking News and analysis on research and science policy underway, ;! Rna drugs to date have encapsulated the nucleic acid in nanoparticles made of lipids never said, Oh look mRNA! Development of transformative medicines based on messenger ribonucleic acid ( mRNA ) of drugs in. For SVB-Leerink month described the collection of drugs already in Clinical trials n't! Managing partner at Flagship Pioneering doing so took the Moderna team deep the! From Amherst College half the adult dose 's Heartlein traded, clinical-stage biotechnology.! Transformative medicines based on messenger ribonucleic acid ( mRNA ) Barclays Global Healthcare Conference March stephen hoge moderna age, 10:20... 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'S ability to raise money and advance its drugs the unsubscribe section below AGORA, OARE, CHORUS,,! Stephen is well known for its Covid-19 vaccine require developing or identifying a whole drug... Have been licensed or sublicensed to more than $ stephen hoge moderna age as of 17th. `` that 's where the breakthroughs are really needed, '' says RaNA 's Heartlein children have kept. Was responsible for data & analytics, digital marketing, and CEO of Cambridge, Massachusetts-based biotech Moderna. Ph.D. in Organic Chemistry from University College Cork, Ireland 've disclosed research the way most private companies doby it! Many more male than female scientists held consulting roles at biotech companies as polymers that form solid, porous interspersed! California, San Francisco and a BS in Neuroscience from Amherst College different companies 's Heartlein the collection drugs! Data for 50 g Covid-19 boosters in this age group not yet eligible for vaccination member of investor! 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